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Document 3130
DOCN M94A3130
TI HIV infection in women in Argentina five years observational study.
DT 9412
AU Lupo S; Santarelli MT; Kneitschel R; Bortolozzi R; Navarret N; Taborda
M; Hospital Centenario, University of Rosario, Argentina.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):147 (abstract no. PB0013). Unique
Identifier : AIDSLINE ICA10/94369445
AB OBJECTIVE: to describe the epidemiology, clinical aspects and
antiretroviral therapy in a group of HIV (+) in Rosario City, Argentina.
MATERIAL: since 1988 until 9/93 a total of 87 HIV (+) women were
followed in our institution. Median age was 26 range (15-55); 16%
initial stage 4 (WHO Staging System); heterosexual transmission 67%,
IVDU 31%, blood transfusion 2%; married 43%, single 44%, 59% had
children, 3% pregnant women; 60% male sexual partners with positive
serology; median baseline CD4 count 605 range (69-1192) and baseline
lymphocytes count 1848 range (456-3350). Median event times were
estimated from Kaplan-Meier curves. RESULTS: heterosexual transmission
58/87 (67%) was the dominant route in our population. Nine (10%) of
children had positive serology for HIV, one of them is dead. More
frequent opportunistic infections more frequent were: PCP 17 (19%),
Tuberculosis 8 (9%) and Cryptococcal meningitis 5 (6%). Forty-one pts
received antiretroviral therapy: AZT (46%), DDI (3%) and AZT+DDC (11%),
median time to treatment was 25 months (mo); estimated SV at 60 mo was:
85% and 71% (p = 0.6789) for pts with or without therapy respectively.
Twenty-nine (33%) pts progressed to stage 4 with a median time to
progression of 42 mo and 10 pts died; estimated probability of survival
was 74% at 60 mo. CONCLUSION: 47% of patients started antiretroviral
therapy due to progression of HIV infection. Heterosexual transmission
was the predominant way in this population. PCP was the most frequent
complication and Tuberculosis (pulmonary 3, extrapulmonary 5) was the
second opportunistic infection. There was no neoplastic complications.
DE Adolescence Adult Antiviral Agents/THERAPEUTIC USE Female Human HIV
Infections/*EPIDEMIOLOGY/MORTALITY/TRANSMISSION Middle Age Probability
Sex Behavior Survival Analysis Time Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).